[Effect of carbamate pesticides on the induction of hepatic enzymes of the rat and on the microsomal phospholipid changes]. / Etude de l'influence des pesticides carbamines sur l'induction des enzymes hépatiques du rat et sur les modifications des phospholipides microsomaux.

The influence of two carbamine pesticides i.e., manebe and carbaryl upon the hepatic microsomal enzymes induction in the rat was studied. Both substances, when administered by themselves, affect only slightly liver weight, P 450 cytochrome rates and bilirubin glucuronosyltransferase, in the microsome fraction of the hepatic homogenate. It seems, however, that carbaryl is involved in producing a slight induction, whereas manebe acts inversely. Yet, manebe changes largely the induction effects of phenobarbital when associated with the latter. In the animal treated simultaneously with manebe and phenobarbital, the increase in the rate of hepatic microsomal P 450 cytochrome as well as the variations in the distribution of fatty acids in phospholipids, are significantly lower than in the animal solely treated with phenobarbital.

Etude de l'influence des pesticides carbamines sur l'induction des enzyes hepatiques du rat et sur les modifications des phospholipides microsomaux. / Effect of carbamate pesticides on the induction of hepatic enzymes of rats and on the microsomal phospholipid changes

Se estudio la influencia de dos pesticidas carbaminados: El Manebe y el Carbaryl sobre las enzimas de los microsomas hepaticos que son inducibles en la rata. Se encontro que las dos substancias ensayadas por si mismas tienen efectos de poca importancia en el peso del higado y en el tenor de citocromo P 450 y de bilirubina glucuronosil transferasa de la fraccion microsomal del homogeneizado hepatico. Parece ser, sin embargo, que el Carbaryl provoca una pequena induccion mientras que el Manebe produce un efecto inverso. Por otra parte, el Manebe modifica muy sensiblemente los efectos inductores del fenobarbital al asociarse a este ultimo. Asi, en el animal tratado simultaneamente con Manebe y fenobarbital, el incremento del tenor de citocromo P 450 hepatico, asi como las variaciones de la reparticion de los acidos grasos en los fosfolipidos son netamente de menor importancia que en los animales tratados unicamente con el fenobarbital